If anyone is interested in touring with their CBR250R, here is a system that I think will work well. I've used it on a 3200km camping trip across Ontario on my CBR125R and plan to use it on a similar camping trip to Toronto on my CBR250R at the end of this month.
A few months ago I purchased the larger Nelson-Rigg Saddlebags for my CBR250R found here:
These will allow me to carry more gear and to keep the heavier stuff lower on the bike. I really like how easy and convenient the Nelson-Rigg system works and how well the clips made all my gear feel secure on my CBR125R. Based on suggestions found on adventure riding forums, I have replaced my Nelson Rigg Tail Bag with a waterproof duffel bag found here:
The straps on the Cabelas duffel bag conveniently connect with the Nelson-Rigg saddles - like they were made for each other. However, if you went this way too, you would have to change-out the side release buckles on the duffel so that they mate properly with the Nelson-Rigg saddles. I just removed the ones from the Nelson-Rigg tailbag and attached them to the duffel bag. The duffel has about twice as much room as the Nelson-Rigg tailbag, it is waterproof (so no more fooling around with waterproof covers), and soft shelled (so easier to fit certain items), has a nice blue reflective coating for visibility, and a more comfortable (softer) wedge against my back while riding. The duffel also has a convenient carrying handle for times when you need to move the bag around.
Now that I have the CBR250R in my possession, I took a few photos today of the bike with my new Nelson-Rigg Silver Streak saddlebags and Cabela's waterproof duffle-bag attached. I added a few items to the duffle to fill it out a bit. The saddles and duffle fit even better on the CBR250R as it is larger than the CBR125R. My short kayak ratcheting ropes help ensure the load is secure.
I had to pass the forward saddlebag strap under the seat and the rear stap over the seat (instead of both under the seat like with my CBR125R). It still feels very secure.
The bags look larger on the bike than they do in real-life.