It's probably safe to say that taking the stock 250R motor, and building it up to a 341cc displacement* with the 300R crank & a 305cc big bore kit could yield an impressive power gain... but the big unknown is what kind of reliability you'd have with such an engine.
* Besides the obvious need for a programmable fuel controller, I'm thinking that the 250R's stock 38mm throttle body wouldn't flow enough air to feed the 341cc displacement, so that would be another issue to address.
All in all, building a 341cc would certainly add up to some big bucks (assuming you do the whole thing right, with no half measures). Personally, I'd just buy a bigger bike like the KTM RC390, which at the end of the day would probably cost less.