In general, no, but when I move into a different environment, a different country, if even a different area in the same country, there is usually a bit to learn. Each place has its own little quirks and customs about how people behave on the road.Do you guys who have ridden for decades still feel like you are perfecting some subtle detail each time out?
There are differences between bikes too. I have ridden bikes with 3, 4, 5, and 6 speed gear boxes as well as CVT transmissions, where you don't change gear at all.
The standard change pattern is down to first the up for all the rest, with neutral between first and second, but I have ridden bikes with other patterns.
Gear change on the left and rear brake on the right is standard, but I have ridden bikes with it the other way around. Those CVT machines usually have the tear brake on the left hand handle bar.
Whenever I get new tyres there is a difference to get used to, more so with a change of brand.
All in all, it is adjusting more than learning.